| Season(s) |
Quarterback(s) |
| 1960 (AFL) |
Johnny Green (6) / Tommy O’Connell (5) / Richie Lucas (2) / Bob Brodhead (1) |
| 1961 (AFL) |
Johnny Green (5) / Warren Rabb (3) / M.C. Reynolds (3) / Richie Lucas (2) / Tommy O’Connell (1) |
| 1962 (AFL) |
Warren Rabb (7) / Al Dorow (4) / Jack Kemp (3) |
| 1963 (AFL) |
Jack Kemp (12) / Daryle Lamonica (2) |
| 1964 (AFL) |
Jack Kemp (13) / Daryle Lamonica (1) |
| 1965 (AFL) |
Jack Kemp (13) / Daryle Lamonica (1) |
| 1966 (AFL) |
Jack Kemp (14) |
| 1967 (AFL) |
Jack Kemp (11) / Tom Flores (3) |
| 1968 (AFL) |
Dan Darragh (7) / Ed Rutkowski (3) / Kay Stephenson (3) / Tom Flores (1) |
| 1969 (AFL) |
Jack Kemp (11) / Dan Darragh (2) / James Harris (1) |
| 1970 (NFL) |
Dennis Shaw (12) / Dan Darragh (2) |
| 1971 |
Dennis Shaw (12) / James Harris (2) |
| 1972 |
Dennis Shaw (13) / Leo Hart (1) |
| 1973 |
Joe Ferguson (14) |
| 1974 |
Joe Ferguson (14) |
| 1975 |
Joe Ferguson (14) |
| 1976 |
Joe Ferguson (7) / Gary Marangi (7) |
| 1977 |
Joe Ferguson (14) |
| 1978 |
Joe Ferguson (16) |
| 1979 |
Joe Ferguson (16) |
| 1980 |
Joe Ferguson (16) |
| 1981 |
Joe Ferguson (16) |
| 1982 |
Joe Ferguson (9) |
| 1983 |
Joe Ferguson (16) |
| 1984 |
Joe Ferguson (11) / Joe Dufek (5) |
| 1985 |
Vince Ferragamo (9) / Bruce Mathison (7) |
| 1986 |
Jim Kelly (16) |
| 1987 |
Jim Kelly (12) / Brian McClure (1) / Willie Totten (1) / Dan Manucci (1) |
| 1988 |
Jim Kelly (16) |
| 1989 |
Jim Kelly (13) / Frank Reich (3) |
| 1990 |
Jim Kelly (14) / Frank Reich (2) |
| 1991 |
Jim Kelly (15) / Frank Reich (1) |
| 1992 |
Jim Kelly (16) |
| 1993 |
Jim Kelly (16) |
| 1994 |
Jim Kelly (14) / Frank Reich (2) |
| 1995 |
Jim Kelly (15) / Todd Collins (1) |
| 1996 |
Jim Kelly (13) / Todd Collins (3) |
| 1997 |
Todd Collins (13) / Alex Van Pelt (3) |
| 1998 |
Doug Flutie (10) / Rob Johnson (6) |
| 1999 |
Doug Flutie (15) / Rob Johnson (1) |
| 2000 |
Rob Johnson (11) / Doug Flutie (5) |
| 2001 |
Alex Van Pelt (8) / Rob Johnson (8) |
| 2002 |
Drew Bledsoe (16) |
| 2003 |
Drew Bledsoe (16) |
| 2004 |
Drew Bledsoe (16) |
| 2005 |
J. P. Losman (8) / Kelly Holcomb (8) |
| 2006 |
J. P. Losman (16) |
| 2007 |
Trent Edwards (9) / J. P. Losman (7) |
| 2008 |
Trent Edwards (14) / J. P. Losman (2) |
| 2009 |
Ryan Fitzpatrick (8) / Trent Edwards (7) / Brian Brohm (1) |
| 2010 |
Ryan Fitzpatrick (13) / Trent Edwards (2) / Brian Brohm (1) |
| 2011 |
Ryan Fitzpatrick (16) |
| 2012 |
Ryan Fitzpatrick (16) |
| 2013 |
EJ Manuel (10) / Thad Lewis (5) / Jeff Tuel (1) |
| 2014 |
Kyle Orton (12) / EJ Manuel (4) |
| 2015 |
Tyrod Taylor (14) / EJ Manuel (2) |
| 2016 |
Tyrod Taylor (15) / EJ Manuel (1) |
| 2017 |
Tyrod Taylor (14) / Nathan Peterman (2) |
| 2018 |
Josh Allen (11) / Nathan Peterman (2) / Derek Anderson (2) / Matt Barkley (1) |
| 2019 |
Josh Allen (16) |
| 2020 |
Josh Allen (16) |
| 2021 |
Josh Allen (7) |
