In Holly Springs, North Carolina, Carlos Rodón attended Holly Springs High School. He has a no-hitter, two one-hitters, and four shutouts during his junior year in 2010. He stands tall at 6 feet 2 inches.
The NCBCA awarded him all-state pitcher after he finished 10–1 with a 0.80 ERA and 115 strikeouts (North Carolina Baseball Coaches Association).
He led Holly Springs to the North Carolina 4A state championship in 2011, going 11–0 with a 1.40 ERA and 135 strikeouts, defeating national powerhouse T. C. Roberson High School.
Rodón was chosen in the 16th round of the 2011 MLB draft by the Milwaukee Brewers. He did not, however, sign a letter of intent to attend NC State University.
On January 30, 2021, Rodón re-signed with the White Sox on a one-year, $3 million contract. Rodón no-hit the Cleveland Indians 8-0 at Guaranteed Rate Field on April 14, 2021.
He missed his attempt for a perfect game on a hit by pitch to Roberto Pérez after retiring the first 25 hitters. Rodón then retired the next two hitters after striking out seven and throwing 75 of 114 pitches for strikes.
Rodón signed a two-year, $44 million contract with the San Francisco Giants on March 14, 2022. He struck out 12 hitters in five innings in his Giants debut on April 8 at Oracle Park, the most strikeouts in a Giants debut since 1960.