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Cal Paul Quantrill (born February 10, 1995) is a Canadian professional baseball pitcher for the Cleveland Guardians of Major League Baseball (MLB). He previously played for the San Diego Padres.

Quantrill was a four-time varsity letterman in baseball at Trinity College School in Port Hope, Ontario, and also lettered in hockey and volleyball. He was drafted by the New York Yankees in the 26th round of the 2013 Major League Baseball draft but did not sign and chose to attend Stanford University.

Heading into the 2016 Major League Baseball draft, Quantrill was ranked as one of the top available players by MLB. He was selected by the San Diego Padres with the eighth overall selection. The Padres signed Quantrill, and assigned him to the Arizona Padres.

They promoted him to the Tri-City Dust Devils in August, and then to the Fort Wayne TinCaps later in the month. He finished the 2016 season with a combined 0–5 record and a 5.11 ERA in 12 starts between the three teams. After the season, Quantrill pitched in the San Diego Padres Futures Game, where he pitched two innings, striking out four.

On August 31, 2020, the Padres traded Quantrill, along with Austin Hedges, Josh Naylor, and minor league players Gabriel Arias, Owen Miller, and Joey Cantillo to the Cleveland Indians for Mike Clevinger, Greg Allen, and Matt Waldron.

With the 2020 Cleveland Indians, Quantrill appeared in 8 games, compiling a 0-0 record with 1.84 ERA and 13 strikeouts in 14+2⁄3 innings pitched.