Maher al-Agal was killed while close to Jindayris, Syria, according to Pentagon Central Command spokesman Lieutenant Colonel Dave Eastburn.
According to US Army Central Command CENTCOM, Maher al-Agal was killed while riding a motorcycle near Jindayris in Syria, and one of his top aides was seriously injured.
According to NBC News, Maher al-Agal was one of the top four ISIS leaders.
According to the Syrian Observatory for Human Rights, Agal was killed by a drone attack.
The Syrian Civil Defense Force said that an attack on a motorcycle near Aleppo killed one person and hurt another, but they did not say who was killed or hurt.
It would be the most recent in a series of strikes against the extremist group in Syria. In an operation last month, the US military says they caught a top ISIS leader and bomb builder who was not named.
The Pentagon says that Abu Ibrahim al-Hashimi al-Qurayshi, the top leader of ISIS, was killed in February by US special forces in northwest Syria. The attack happened at night.
The news of the death of Maher al-Agal arrives just before President Joe Biden departs on a trip to the Middle East.
He is expected to arrive in Israel on Wednesday, where he will hold a number of meetings in Israel and the West Bank before going to Saudi Arabia.
Where Was ISIS Leader Maher al-Agal Killed?
ISIS Leader Maher al-Agal was killed near Jindayris in Syria. The airstrike was conducted outside Jimdahtis, northwest Syria, according to Israeli news outlet Belaaz News.